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KMID : 0378019750180060755
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New Medical Journal
1975 Volume.18 No. 6 p.755 ~ p.763
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Histochemical studies on the liver cells of carbon monoxide poisoned rat
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Abstract
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The present investigation was undertaken with the aim of studying the effect of carbon monoxide on the cytoplasmic RNA and nuclear DNA content of hepatic cells in rat. For this purpose, rat was poisoned to 0. 1%, 0.25 % and 0.5 % carbon monoxide for 15 minutes to 24 hours. The RNA and DNA content was determined by the histochemical method.
The following results were obtained:
1. The decrement of RNA content was began at 8 hours after 0. 1 % carbon monoxide poisoning and was continued until 24 hours but DNA content changed at 24 hours.
2. In 0.25% carbon monoxide poisoning group, the decrease of RNA and DNA content was began at 2 hours after poisoning and was continued until 4 hours.
3. In 0.5% carbon monoxide poisoning group, the RNA content decreased at 30 minutes after poisoning but was continued 60 minutes. The decrement of DNA content was at 60 minutes.
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